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Archive for the '0-9' Category

1,3-N-Dipropyl-7-Propargylxanthine

Also written (correctly) as 1,3-di-n-propyl-7-propargylxanthine. A synthetic caffeine analog that is reportedly 100 times more potent than caffeine at both A1 and A2 adensosine receptors.  It has not, however, been tested in humans.

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3′,5,7-Trihydroxy-4′-Methoxyflavone-7-Rutinoside

See Diosmin.

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1,4,6-Androstatriene-3,17-Dione

See ATD.

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4-Hydroxy-3-Methoxy Cinnamic Acid

See Ferulic Acid.

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2a,3a-Epithio-17a-Methyl-5a-Androstan-17b-Ol

An anabolic “supplement” compound sold under various names (Havoc, Epistane, Hemaguno). It’s a methylated, orally-bioavailable version of a steroidal, anti-estrogenic drug, Epitiostanol, which was originally developed in Japan.  Epitiostanol is also the parent compound of an illegal anabolic steroid: Mepitiostane (2a, 3a-epithio-5-androstan-17b-yl-1-methoxycyclopentyl ether).

May also be written as 2a,3a-epithio-17a-methyletioallocholanol. While it’s currently being sold on the open market, 2a,3a-epithio-17a-methyl-5a-androstan-17b-ol is of dubious legality, and unlikely to withstand FDA scrutiny.

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3,5-Diiodo-L-Thyronine

Also known as 3,5-T2 or T2.  Like 3,3′-diiodo-l-thyronine, it’s a breakdown metabolite of the active thyroid hormone, T3.  Animal data suggests it can reduce body fat accumulation by reducing oxidative stress and altering hepatic (liver) fat metabolism - without inducing thyrotoxicity.  This is why it’s included in several weight loss supplements, although a) there’s no controlled human data on its use for this purpose; and b) there is little available info on its oral pharmacokinetics (or dose) - the animals in the studies were injected with 3,5-T2, not fed/gavaged.

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3,3′-Diiodo-L-Thyronine

Also known as 3,3′ T2.  A breakdown metabolite of the active (T3) thyroid hormone, 3,3′,5-triiodo-L-thyronine.  It’s included in some weight loss supplements as a “thyromimetic” compound, although there is no human data to support its use for this purpose.  There is limited animal data that demonstrates it can increase metabolic rate and energy expenditure, but the 3,3′-diiodo-l-thyronine was administered by injection – not orally.

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4-Hydroxyandrostenedione

See Formestane.

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1-Androsterone

Androsterone (ADT)  is a testosterone metabolite that is secreted in sweat and excreted in urine.  It’s a reputed pheromone and weak androgen.  1-Androsterone has a double bond at C-1, and is alleged to be a prohormone for 1-testosterone, a potent anabolic steroid and Schedule III controlled substance.  Unlike the now-banned prohormones, however, more than one enzymatic step is required to convert 1-androsterone to the target hormone.

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Cis-9,10-Octadecenoamide

Also known as oleamide.  A naturally-occurring derivative of oleic acid (a monounsaturated fatty acid) that induces sleep.  Research is ongoing, but in-vitro and rodent experiments indicate it may have other functions as well.  For example, it may have anxiolytic (anxiety-reducing) and anti-convulsant activities.  Oleamide derivatives also inhibit the metastasis of cancer cells in-vitro.

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